TABLE 1.

Estimates of the DDME for D. melanogaster

Shape	Location	Lethals	Nes(am)	Nes(hm)	Nes (5%)	Nes (95%)	CV	cne %
1.35	2.85 × 10−6	<10−100	3.87	3.54	2.17	6.16	0.308	0.0040
2.72	4.25 × 10−6	10−36	9.46	4.18	1.46	30.3	1.27	4.41
3.67	5.43 × 10−6	4 × 10−22	17.5	4.83	1.46	62.1	2.02	6.68
7.39	1.02 × 10−5	3.4 × 10−10	108	6.39	1.58	394	6.81	9.81
10	1.37 × 10−5	4.3 × 10−8	279	7.58	1.6	910	10.4	10.6
20	2.71 × 10−5	1.7 × 10−5	2,460	9.76	1.84	5,820	9.65	11.7
30	4.07 × 10−5	0.00011	6,530	11.1	1.87	17,000	7.23	12.2
40	5.47 × 10−5	0.00029	11,100	12.0	2.00	34,100	5.98	12.4
50	6.86 × 10−5	0.00053	15,500	12.7	2.02	54,400	5.26	12.6
60	8.27 × 10−5	0.00080	19,500	13.3	2.15	79,300	4.8	12.7
70	9.69 × 10−5	0.0011	23,200	13.7	2.16	101,000	4.48	12.8
80	0.000111	0.0014	26,400	14.1	2.17	126,000	4.24	12.8
90	0.000126	0.0017	29,400	14.4	2.19	148,000	4.6	12.9
100	0.000140	0.0020	32,000	14.7	2.32	171,000	3.91	12.9

All estimates are consistent with diversity data from D. melanogaster. The values underlined, for the predicted frequencies of effectively lethal, dominant mutations, are consistent with genetic data (∼10⁻⁵–0.004/zygote/generation; see Loewe and Charlesworth 2006). Columns denote the shape, σ_g, and location, μ_g, of the assumed lognormal DDME; the number of dominant, effectively lethal mutations per genome per generation predicted by the DDME; the arithmetic (am) and harmonic (hm) mean selection coefficient multiplied by N_e (averaged over the truncated DDME, including all nonneutral, nonlethal mutations); the lower (5%) and upper (95%) 5% percentiles of the truncated DDME; the coefficient of variation of the truncated DDME; and c_ne %, the percentage of effectively neutral nonsynonymous mutations.