TABLE 2.

Maximum-likelihood estimates of deleterious mutation rate per diploid genome, U, and mean heterozygous effect, s, for fitness traits in Saccharomyces cerevisiae derived from MA experiments on nonmutator strains

U estimate (95% C.I.)	s estimate (95% C.I.)	Fitness trait	Reference
5.5 × 10−5a	0.217a	Growth rate via competition experiments	Zeyl and DeVisser (2001)
(3.5 × 10−5–1.5 × 10−4)a	(0.208–0.236)a
1.2 × 10−4b	0.061b	Maximum growth rate via sliding-window program	Joseph and Hall (2004)
(4.6 × 10−5–∞)b	(0–0.077)b
1.3 × 10−2c	0.0046c	Sporulation rate via the proportion of asci	This study
(4.8 × 10−3–3.2 × 10−2)d	(0.0019–0.020)d
(8 × 10−5–∞)c	(0–0.50)c
3 × 10−4c	0.017c	Maximum growth rate via sliding-window program	This study
(6 × 10−5–1.1 × 10−3)e	(0.006–0.033)e
(6 × 10−5–∞)c	(0–0.033)c

These estimates have not been corrected for selection during colony growth; see Zeyl and DeVisser (2001) and Joseph and Hall (2004) for corrections.

^aEstimated with β = 60, which yielded the ML fit.

^bEstimated with β and P allowed to vary; includes petite mutations.

^cEstimated with β and P allowed to vary.

^dEstimated with β = 0.01 and P = 0, which yielded the ML fit.

^eEstimated with β = ∞ and P = 0, which yielded the ML fit.