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The inhibitory activity of OxPAPC and POVPC involves a PKA-mediated mechanism. HAEC were pretreated with H89 (25 μmol/liter) for 1 h at 37°C and then coincubated with LPS (2 ng/ml) and either POVPC (1 μmol/liter) or OxPAPC (5 μmol/liter) for 4 h at 37°C in the presence or absence of 25 μmol/liter H89. Surface expression of E-selectin was determined by cell surface ELISA. Data are representative of four independent experiments.
