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. 1999 Oct 12;96(21):12027–12032. doi: 10.1073/pnas.96.21.12027

Figure 2.

Figure 2

Uterine growth and development in F2 offspring. (A) Estimation of size of uteri in 10-week-old F2 offspring. Several uteri with secretory phase in menstrual cycle were collected. Underdevelopment in homozygous mice (−/−) as compared with wild-type mice (+/+) is actually shown. (B) Evaluation of uterine development in F2 offspring. The ratio of uterine wet weight (milligrams) to body weight (grams) was calculated, and the ratio in homozygous mice (−/−) (n = 11) is lower than in wild-type mice by 36%. The t test shows a significant difference (P < 0.05) between wild-type mice (+/+) (n = 8) and homozygotes (−/−) (n = 11).