Table 1.
Classification of seizure scores in PPT-A(+/+) and PPT-A(−/−) mice after systemic administration of kainate and PTZ
| Mouse type | Dose mg | Seizure scores, % of mice
|
Mortality | |||||
|---|---|---|---|---|---|---|---|---|
| Stage 1 | Stage 2 | Stage 3 | Stage 4 | Stage 5 | Stage 6 | |||
| WT (n = 6) | 25 (KA) | 6 (100) | 6 (100) | 6 (100) | 4 (66) | 3 (50) | 1 (17) | 0 (0) |
| KO (n = 6) | 25 (KA) | 6 (100) | 6 (100) | 4 (66) | 1 (16)a | 0 (0)c | 0 (0) | 0 (0) |
| WT (n = 20) | 35 (KA) | 20 (100) | 20 (100) | 18 (90) | 16 (80) | 14 (70) | 10 (50) | 6 (30) |
| KO (n = 10) | 35 (KA) | 10 (100) | 10 (100) | 8 (80) | 5 (50)a | 1 (12)c | 1 (10)b | 1 (10)a |
| WT (n = 12) | 50 (PTZ) | 12 (100) | 12 (100) | 12 (100) | 8 (66) | 7 (58) | ||
| KO (n = 10) | 50 (PTZ) | 10 (100) | 10 (100) | 8 (80) | 3 (30)a | 1 (10)c | ||
WT, PPT-A(+/+); KO, PPT-A(−/−). Comparison of seizure responses between WT and KO mice. KA, kainate. a, P < 0.05; b, P < 0.01; c, P < 0.001.