Figure 1.

Representative Western blots of APP with 22C11 in normal rats. (A) Levels of cell-associated, full-length APP were reduced in the presence of RS86 (indicated by +) related to those in the absence of RS86 (indicated by −) in cerebral cortex. (B) Decreased levels of cell-associated, full-length APP are found in the presence of RS86 (+) related to those in the absence (−) of RS86 in hippocampus. (C) No such changes were observed in the presence (+) and absence (−) of RS86 in striatum. (D) Secreted form of APP in CSF was immunoprecipitated and probed with 22C11. The levels of APPs were increased by RS86 (+) compared with vehicle (−).