Figure 2.

Synaptic transmission at waggler pf-PC synapse is reduced. (A) PPF is significantly enhanced at young wild-type and adult waggler pf-PC synapses over the intervals ranging from 50 to 300 ms. Raising extracellular [Ca²⁺]/[Mg²⁺] from 3 to 6 reduced PPF of adult waggler and young wild-type synapses to adult wild-type level. (B) Input–output relations at adult pf-PC synapses. Each line represents responses recorded from an individual Purkinje cell. With gradually increased intensity of parallel fiber stimulation, pf-PC EPSPs exhibited smaller slopes of the input–output function and lower maximal responses in wagglers than wild types. The Insets represent typical examples of EPSP traces from both groups (marked with asterisk).