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DA−/− mice exhibit hyperactivity immediately after l-DOPA treatment, and display a second wave of activity that occurs 30 hr after treatment. Ambulatory activity of DA−/− mice (A; n = 17] and WT mice (B; n = 8). (C and D) Black bars represent the dark cycle. Total distance traveled and amount of food consumed by DA−/− and WT mice in the first 24-hr period (C) and second 24-hr period (D) after l-DOPA treatment.
