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Low doses of l-DOPA cause hyperactivity in DA−/− mice. Individually housed DA−/− mice during the 9-hr period after administration of 10, 20, 30, 40, or 50 mg/kg or 100 mg/kg l-DOPA methyl ester were used to generate a dose-response curve. Various doses of l-DOPA were administered 24 hr after their last l-DOPA injection. (A) Ambulatory activity of WT (n = 8) and DA−/− mice (n = 8). (B) Food consumed by WT (n = 8) and DA−/− mice (n = 8).
