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DA receptor antagonists do not block the second wave of locomotion displayed by DA−/− mice. Ambulatory activity of WT and DA−/− mice treated with 0.9% saline (open bars) or a mixture of 0.1 mg/kg SCH 23390 and 2 mg/kg haloperidol (closed bars) shown as percent of saline-elicited activity. Meters traveled ± SEM: WT saline = 24.6 ± 6.2; DA−/− saline (2–6 hr) = 281.1 ± 59.3; and DA−/− saline (26–30 hr) = 17.9 ± 6.7.
