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Amphetamine induces locomotor behavior in DA−/− mice, but amphetamine treatment does not block the second wave of activity displayed by DA −/− mice. (A) Ambulatory activity of WT and DA−/− mice given two consecutive injections of 5 mg/kg amphetamine. Arrows indicate times of amphetamine administration. (B) Amphetamine (5 mg/kg) was administered 19 hr after the l-DOPA injection and activity was monitored for an additional 36 hr. Arrow indicates time of amphetamine injection.
