Skip to main content
. 1999 Oct 12;96(21):12138–12143. doi: 10.1073/pnas.96.21.12138

Figure 6.

Figure 6

Simultaneous carbidopa and l-DOPA treatment induces stereotypy in DA−/− mice. (A) Ambulatory activity of DA −/− mice (n = 8) treated with 50 mg/kg l-DOPA (■) or a mixture of 50 mg/kg l-DOPA and 12.5 mg/kg carbidopa (□) parse by 1-hr intervals. (B) Total meters traveled and food consumed by DA−/− mice in the first 3 hr after injection of 50 mg/kg l-DOPA alone (black bars) or 50 mg/kg l-DOPA and 12.5 mg/kg carbidopa (open bars). (C) Total meters traveled and food consumed by DA−/− mice in 24 hr when treated with 50 mg/kg l-DOPA alone (black bars), a mixture of 50 mg/kg l-DOPA and 12.5 mg/kg (open bars), or 50 mg/kg l-DOPA and 25 mg/kg carbidopa (gray bars).