Table 1.

Neurological testing of WT and DA−/− mice

Test		Test score
		WT 24 hr	DA−/− mice
			1 hr	24 hr
Screen paw placement		40	40	40
One-limb akinesia		39	40	14***
Four-limb akinesia		40	40	9***
Turning on a tilted screen		35	29	7**
Forelimb catalepsy		40	39	14***
Visual placing		36	39	32
Orientation to paw pinch		40	33*	37
Auditory response		40	40	40
Vestibular response		40	40	40
Splay posture		40	40	40
Biting strength		25	26	26
Righting reflex		40	40	40
Hind-limb extensor rigidity		40	40	40
	Total	495	486	379

Neurological tests were performed on WT and DA−/− mice 1 and 24 hr after l-DOPA treatment. No differences were observed in WT mice at 1 and 24 hr. Maximum possible score for each test was 40 (4 × 10 mice). Significance was assessed by standard ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with WT mice.