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Diazoxide activation of SUR2A/Kir6.2 KATP channels does not require the presence of ATP but requires Mg2+. (A) Activation by diazoxide (300 μM) of SUR2A/Kir6.2 KATP channels in the presence of ADP (1 mM) as the only blocking nucleotide with 1 mM Mg2+. In five different patches, current in diazoxide relative to control was 2.03 ± 0.37. (B) Idem in the absence of Mg2+ with 5 mM EDTA to chelate contaminant Mg2+. Both traces are from the same patch.
