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. 1999 Oct 12;96(21):12162–12167. doi: 10.1073/pnas.96.21.12162

Figure 4.

Figure 4

Point mutations in Walker A and Walker B motifs of the second nucleotide binding domain of SUR2A impair the ability of ADP to promote diazoxide activation. (A) Lack of effect of diazoxide (300 μM) and ADP on KATP channels from an oocyte expressing wild-type Kir6.2 and mutated SUR2A with a K1348M mutation in the second Walker A motif. (B) Idem with the Walker B mutant D1469N of SUR2A. (C) Average effects of diazoxide, ADP, and diazoxide plus ADP on wild-type and mutant SUR2A/Kir6.2 currents.