Table 4.
Hepatic GSH levels after treatment with Pb(NO3)2, GdCl3 or with 24 hours pretreatment of GdCl3 before exposure to Pb(NO3)2 .*
| Weeks | Untreated / BSO | PbNO3 | GdCl3 | GdCl3 / PbNO3 | |||
| 3 days | 5 days | 3 days | 5 days | 3 days | 5 days | ||
| - | 29.00 | ||||||
| 1 | 17.76 {- 3%} | 13.80 | 11.02 | 14.05 | 16.03 | 16.03 | 18.09 |
| 2 | 9.65 {- 47%} | 8.50 | 5.70 | 8.90 | 11.02 | 6.20 | 10.10 |
| 3 | 5.09 {- 72%} | 6.65 | 4.30 | 6.42 | 7.90 | 6.10 | 8.80 |
* GSH values are given as nmol / mg protein. Animals were fed with 2 mM BSO for 1, 2 or 3 weeks before injection with the different heavy metals, and the GSH content was evaluated at 3 and 5 days after the injection. Standard deviations did not exceed 5%. In brackets is the percentage of decrement of GSH levels relative to control untreated animals. Each value is the mean of 3 independent experiments, using 3 different animals.