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. 2003 Aug 7;2:28. doi: 10.1186/1476-4598-2-28

Figure 10.

Figure 10

Hypothesis about an alternate TGFβ1 signaling pathway via αVβ6 integrin, independent of RGD. This pathway may be required for full TGFβ1 induced transcriptional activation, which explains the TGFβ1 sensitivity of those cells lacking DPC4/SMAD4 function that still react with growth inhibition.