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p460 and the Ku–p460 complex are both specifically activated by DNA ends. Kinase activities of p460 or of Ku–p460 complexes were measured using different forms of plasmid DNA as substrate. Plasmid DNA was linearized with BamHI, digested to 15 fragments with DpnI, or left as supercoiled DNA and incubated with p460 (35 ng) with or without Ku (11 ng) in buffer C containing 50 mM NaCl.
