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. Author manuscript; available in PMC: 2007 Oct 30.
Published in final edited form as: Brain Res. 2006 Sep 7;1117(1):38–53. doi: 10.1016/j.brainres.2006.08.016

Fig. 4.

Fig. 4

Mean changes in temperature (A,B) and locomotion (C) following a series of ten iv injections of cocaine, procaine and cocaine methiodide in awake, unrestrained rats during DA receptor blockade. A= relative temperature change with respect to the last pre-injection value. B= NAcc-Muscle and Skin-Muscle temperature differentials. Filled symbols show values significantly different (p<0.05) from the last-pre-injection value. The effect of time on both temperature and movement was statistically evaluated for each drug with one-way ANOVA with repeated measures. F values (NAcc, skin, muscle, and movement, respectively) were for cocaine: F20,650=11.40, 14.29, 24.43, and 15.98; procaine: F20,650=11.40, 14.29, 24.43,15.98; for cocaine-methiodide: F20,650=11.40, 14.29, 24.43, and 15.98. All values indicate significant effect, with p<0.01. Vertical hatched lines show the moments of drug injection and horizontal hatched line show basal values preceding the first drug injection.