Mean changes in temperature following the initial (A) and repeated (B) injections of cocaine, procaine and cocaine methiodide during DA receptor blockade. C=changes in locomotion following repeated injections of each drug. Filled symbols show values significantly different from the last pre-injection value (p<0.05; Scheffe post-hoc test based on significant time effects evaluated by ANOVA with repeated measures). F values of the effect of the initial injections were presented in abbreviations to Fig. 4. F values (NAcc, skin, muscle, and movement, respectively) for repeated injections were for cocaine: F44,404=15.81, 8.28, 7.81, and 0.66 (each, expect movement, is significant with p<0.001); for procaine: F53,485=12.05, 0.62, 9.05, and 0.71 (all, except muscle and movement, are significant with p<0.001); and for cocaine-methiodide: F53,485=2.45, 3.51, 0.85, and 0.87 (each, expect muscle and movement, is significant with p<0.05).