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Schematic representation of the transmembrane segments of the open states of the isolated C-terminal domain of colicin Ia. (A) Normal conductance channel similar to the channel formed by the whole molecule. (B) Small conductance channel, the result of the translocation of H1. The inset shows the electrophysiological record showing the transition from the normal to the small conductance state. The membrane is clamped at +70 mV.
