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. 2007 Mar;71(1):158–229. doi: 10.1128/MMBR.00036-06

FIG. 3.

FIG. 3.

Schematic summary of reception, translocation, and mode of action of most studied colicins. Colicins are distinguished by their general modes of action (upper section, enzymatic; lower section, pore forming) and transit machineries (right section, TonB; left section, Tol) separated by dotted lines. For each colicin (the name is indicated at the arrow base), the outer membrane protein used for the reception step (and sometimes for outer membrane translocation) (ColB, D, Ia, Ib, M, and N) and the OM protein involved in the translocation step (OmpF, colicins A, E2 to E9, K, and U; TolC, colicins 5, 10, and E1) are indicated. For enzymatic colicins, the mode of action at the physiology level (peptidoglycan synthesis block [colicin M], protein synthesis block by cleavage of tRNA [colicins D and E5] or 16S rRNA [colicins E3, E4, and E6], and DNA degradation [colicins E2 and E7 to E9]) is also indicated. For tRNA colicins (colicins D and E5), the specific tRNA targeted is indicated by the one-letter code in parentheses (D, aspartate; H, histidine; N, asparagine; R, arginine; Y, tyrosine). See the text for details.