Table II .
GenBank Accession | Gene Symbol | Gene Title | SIT* | Liver** |
---|---|---|---|---|
Cell Adhesion | ||||
NM_009864 | Cdh1 | Cadherin 1 | 6.77 | |
XM_283264 | Cdh10 | cadherin 10 | 7.01 | |
NM_007664 | Cdh2 | cadherin 2 | 9.72 | |
XM_488510 | Cspg2 | chondroitin sulfate proteoglycan 2 | 2.72 | 2.82 |
NM_009903 | Cldn4 | claudin 4 | 4.86 | |
NM_018777 | Cldn6 | claudin 6 | 2.32 | |
NM_031174 | Dscam | Down syndrome cell adhesion molecule (Dscam) | 2.25 | |
NM_010103 | Edil3 | EGF-like repeats and discoidin I-like domains 3 | 9.2 | |
NM_008401 | Itgam | integrin alpha M | 2.42 | |
NM_008405 | Itgb2l | integrin beta 2-like | 9.64 | |
Jam3 | Junction adhesion molecule 3 | 2.2 | ||
NM_007736 | Col4a5 | procollagen, type IV, alpha 5 | 2.54 | |
XM_139187 | Pcdh9 | protocadherin 9 | 2.33 | |
Apoptosis and Cell cycle control | ||||
XM_194020 | Acvr1c | activin A receptor, type IC | 26.49 | |
NM_178655 | Ank2 | ankyrin 2, brain | 17.4 | |
NM_153287 | Axud1 | AXIN1 up-regulated 1 | 2.71 | |
Bcl2 | B-cell leukemia/lymphoma 2 (Bcl2), transcript variant 1 | 2.68 | ||
NM_009744 | Bcl6 | B-cell leukemia/lymphoma 6 | 2.02 | |
NM_207653 | Cflar | CASP8 and FADD-like apoptosis regulator | 2.12 | |
NM_026373 | Cdk2ap2 | CDK2-associated protein 2 | 2.35 | |
XM_484088 | Cdc27 | cell division cycle 27 homolog (S. cerevisiae) | 2.36 | |
NM_009862 | Cdc45l | cell division cycle 45 homolog (S. cerevisiae)-like | 3.38 | |
NM_026201 | Ccar1 | cell division cycle and apoptosis regulator 1 | 9.84 | |
NM_013538 | Cdca3 | cell division cycle associated 3 | 2.18 | |
NM_011806 | Dmtf1 | cyclin D binding myb-like transcription factor 1 | 2.88 | |
NM_028399 | Ccnt2 | cyclin T2 | 9.26 | |
NM_009874 | Cdk7 | cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) | 15.94 | |
NM_007837 | Ddit3 | DNA-damage inducible transcript 3 | 13.72 | 9 |
NM_007950 | Ereg | epiregulin | 5.85 | |
NM_008087 | Gas2 | Growth arrest specific 2 | 2.01 | |
XM_137276 | Gas2l3 | growth arrest-specific 2 like 3 | 4.26 | |
NM_146071 | Muc20 | mucin 20 | 2.96 | |
NM_009044 | Rel | reticuloendotheliosis oncogene | 2.35 | |
NM_133810 | Stk17b | serine/threonine kinase 17b (apoptosis-inducing) | 2.27 | |
NM_028769 | Syvn1 | synovial apoptosis inhibitor 1, synoviolin | 4.77 | |
NM_021897 | Trp53inp1 | transformation related protein 53 inducible nuclear protein 1 | 2.49 | |
Biosynthesis and Metabolism | ||||
--- | Acyl-CoA synthetase long-chain family member 5 | 17.14 | ||
NM_029901 | Akr1c21 | aldo-keto reductase family 1, member C21 | 2.14 | |
NM_023179 | Atp6v1g2 | ATPase, H+ transporting, V1 subunit G isoform 2 | 2.23 | |
1451144_at | Bxdc2 | brix domain containing 2 | 2.19 | |
NM_023525 | Cad | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 2.4 | |
NM_198415 | Ckmt2 | creatine kinase, mitochondrial 2 | 29.85 | |
NM_007710 | Ckm | creatine kinase, muscle | 21.08 | |
NM_030225 | Dlst | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 3.28 | |
NM_021896 | Gucy1a3 | guanylate cyclase 1, soluble, alpha 3 | 5.6 | |
NM_011846 | Mmp17 | matrix metallopeptidase 17 | 24.22 | |
NM_138656 | Mvd | mevalonate (diphospho) decarboxylase | 3.46 | |
NM_009127 | Scd1 | stearoyl-Coenzyme A desaturase 1 | 2.26 | |
Calcium homeostasis | ||||
NM_013471 | Anxa4 | Annexin A4 | 5.2 | |
NM_009722 | Atp2a2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 2.65 | |
NM_023116 | Cacnb2 | Calcium channel, voltage-dependent, beta 2 subunit | 14.13 | |
NM_009781 | Cacna1c | Calcium channel, voltage-dependent, L type, alpha 1C subunit | 7.94 | |
NM_028231 | Kcnmb2 | potassium large conductance calcium-activated channel, subfamily M, beta member 2 | 4.62 | |
Cell Growth and Differentiation | ||||
NM_010111 | Efnb2 | ephrin B2 | 2.67 | |
NM_177390 | Myo1d | Myosin ID | 2.68 | |
NM_145610 | Ppan | peter pan homolog (Drosophila) | 2.04 | |
NM_021883 | Tmod1 | tropomodulin 1 | 2.7 | |
NM_009394 | Tnnc2 | troponin C2, fast | 16.76 | |
ER/Golgi transport and ER/Golgi biosynthesis/metabolism | ||||
NM_025445 | Arfgap3 | ADP-ribosylation factor GTPase activating protein 3 | 2.58 | |
NM_025505 | Blzf1 | basic leucine zipper nuclear factor 1 | 7.72 | |
NM_009938 | Copa | coatomer protein complex subunit alpha | 2.4 | |
NM_025673 | Golph3 | Golgi phosphoprotein 3 | 2.57 | |
NM_146133 | Golph3l | golgi phosphoprotein 3-like | 2.41 | |
NM_008408 | Itm1 | intergral membrane protein 1 | 6.62 | 2.56 |
NM_027400 | Lman1 | Lectin, mannose-binding | 2.79 | |
NM_025408 | Phca | phytoceramidase, alkaline | 3.04 | |
NM_009178 | Siat4c | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | 2.4 | |
NM_020283 | B3galt1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 2.54 | |
NM_011716 | Wfs1 | Wolfram syndrome 1 homolog (human) | 2.02 | |
Electron Transport | ||||
NM_015751 | Abce1 | ATP-binding cassette, sub-family E (OABP), member 1 | 2.48 | |
NM_010001 | Cyp2c37 | cytochrome P450, family 2. subfamily c, polypeptide 37 | 5.58 | |
NM_023913 | Ern1 | Endoplasmic reticulum (ER) to nucleus signalling 1 | 2.12 | |
XM_129326 | Gucy2g | guanylate cyclase 2g | 2.39 | |
NM_007952 | Pdia3 | protein disulfide isomerase associated 3 | 3.11 | |
NM_009787 | Pdia4 | protein disulfide isomerase associated 4 | 3.19 | |
XM_907880 | Pdia6 | protein disulfide isomerase associated 6 | 2.9 | |
XM_284053 | Steap2 | six transmembrane epithelial antigen of prostate 2 | 3.23 | |
NM_198295 | 730024F05Ri | Thioredoxin domain containing 10 | 2.91 | |
NM_029572 | Txndc4 | thioredoxin domain containing 4 (endoplasmic reticulum) | 2.47 | |
NM_023140 | Txnl2 | Thioredoxin-like 2 | 8.25 | |
G-protein coupled receptors | ||||
NM_008158 | Gpr27 | G protein-coupled receptor 27 | 2.72 | |
NM_145066 | Gpr85 | G protein-coupled receptor 85 | 3.78 | |
AK015353 | Grm2 | G protein-coupled receptor, family C, group 1, member B | 2.18 | |
NM_008177 | Grpr | gastrin releasing peptide receptor | 2.18 | |
NM_010314 | Gngt1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 2.02 | |
NM_139270 | Pthr2 | parathyroid hormone receptor 2 | 2.12 | |
NM_011056 | Pde4d | phosphodiesterase 4D, cAMP specific | 2.78 | |
NM_022881 | Rgs18 | regulator of G-protein signaling 18 | 2.36 | |
Kinases and Phosphatases | ||||
NM_153066 | Ak5 | adenylate kinase 5 | 2.33 | |
NM_144817 | Camk1g | calcium/calmodulin-dependent protein kinase I gamma | 2.32 | |
NM_139059 | Csnk1d | Casein kinase 1, delta (Csnk1d), transcript variant 2 | 2.08 | |
NM_177914 | MGI:3580254 | diacylglycerol kinase kappa | 13.2 | |
NM_130447 | Dusp16 | dual specificity phosphatase 16 | 3.17 | 2.13 |
NM_019987 | Ick | intestinal cell kinase | 2.06 | |
XM_283179 | Mast4 | microtubule associated serine/threonine kinase family member 4 | 3.62 | |
NM_016700 | Mapk8 | mitogen activated protein kinase 8 | 12.43 | |
Mapk8 | mitogen activated protein kinase 8 | 7.41 | ||
NM_172688 | Map3k7 | mitogen activated protein kinase kinase kinase 7 | 3.29 | |
NM_011101 | Prkca | Protein kinase C, alpha | 2.04 | |
NM_011104 | Prkce | protein kinase C, epsilon | 3.3 | |
NM_021880 | Prkar1a | protein kinase, cAMP dependent regulatory, type I, alpha | 15.23 | |
NM_175638 | Prkwnk4 | Protein kinase, lysine deficient 4 | 8.16 | |
NM_016979 | Prkx | protein kinase, X-linked | 2.27 | |
NM_133485 | Ppp1r14c | Protein phosphatase 1, regulatory (inhibitor) subunit 14c | 5.03 | |
NM_012024 | Ppp2r5e | protein phosphatase 2, regulatory subunit B (B56), epsilon isoform | 2.49 | |
NM_008913 | Ppp3ca | Protein phosphatase 3, catalytic subunit, alpha isoform | 14.5 | |
AK134422 | Ptp | Protein tyrosine phosphatase | 3.27 | |
NM_028259 | Rps6kb1 | ribosomal protein S6 kinase, polypeptide 1 | 2.05 | |
NM_031880 | Tnk1 | tyrosine kinase, non-receptor, 1 | 2.54 | |
Nuclear Assembly and Processing | ||||
NM_010613 | Khsrp | KH-type splicing regulatory protein | 2.44 | |
NM_008671 | Nap1l2 | nucleosome assembly protein 1-like 2 | 4.7 | |
NM_026175 | Sf3a1 | splicing factor 3a, subunit 1 | 2.77 | |
NM_009408 | Top1 | Topoisomerase (DNA) I | 5.94 | |
NM_008717 | Zfml | Zinc finger, matrin-like | 2.19 | |
Glucose biosynthesis/metabolism | ||||
NM_009605 | Adipoq | adiponectin, C1Q and collagen domain containing | 2.23 | |
NM_018763 | Chst2 | Carbohydrate sulfotransferase 2 | 2.02 | |
NM_008079 | Galc | galactosylceramidase | 2.95 | |
NM_029626 | Glt8d1 | glycosyltransferase 8 domain containing 1 | 2.17 | |
NM_013820 | Hk2 | hexokinase 2 | 2.46 | |
NM_010705 | Lgals3 | Lectin, galactose binding, soluble 3 | 3.2 | |
NM_199446 | Phkb | phosphorylase kinase beta | 2.06 | |
NM_016752 | Slc35b1 | solute carrier family 35, member B1 | 2.13 | |
Signaling molecules and interacting partners | ||||
NM_029291 | Ascc2 | Activating signal cointegrator 1 complex subunit 2 | 3.24 | |
NM_007498 | Atf3 | activating transcription factor 3 | 8.73 | |
NM_016707 | Bcl11a | B-cell CLL/lymphoma 11A (zinc finger protein) | 4.2 | |
NM_033601 | Bcl3 | B-cell leukemia/lymphoma 3 | 2.08 | |
NM_007553 | Bmp2 | bone morphogenetic protein 2 | 2.55 | |
NM_007558 | Bmp8a | bone morphogenetic protein 8a | 2.39 | |
NM_178661 | Creb3l2 | cAMP responsive element binding protein 3-like 2 | 2.01 | |
NM_010016 | Daf1 | decay accelerating factor 1 | 2.29 | |
NM_007897 | Ebf1 | early B-cell factor 1 | 8.98 | |
NM_023580 | Epha1 | Eph receptor A1 | 2.037 | |
NM_133753 | Errfi1 | ERBB receptor feedback inhibitor 1 | 2.53 | |
NM_0010058 | Erbb2ip | Erbb2 interacting protein | 2.11 | |
NM_0010058 | Erbb2ip | Erbb2 interacting protein | 2.04 | |
NM_007906 | Eef1a2 | eukaryotic translation elongation factor 1 alpha 2 | 3.67 | |
NM_007917 | Eif4e | eukaryotic translation initiation factor 4E | 3.05 | |
NM_173363 | Eif5 | eukaryotic translation initiation factor 5 | 2.13 | |
NM_010515 | Igf2r | Insulin-like growth factor 2 receptor | 2.22 | |
NM_010591 | Jun | Jun oncogene | 2.29 | |
NM_010592 | Jund1 | Jun proto-oncogene related gene d1 | 2.43 | |
NM_008416 | Junb | Jun-B oncogene | 2.36 | |
NM_013602 | Mt1 | metallothionein 1 | 2.15 | |
NM_008630 | Mt2 | metallothionein 2 | 2.79 | |
NM_170671 | Mycbpap | Mycbp associated protein | 3.97 | |
NM_177619 | Myst2 | MYST histone acetyltransferase 2 | 2 | |
NM_009123 | Nkx1-2 | NK1 transcription factor related, locus 2 (Drosophila) | 2.45 | |
NM_030612 | Nfkbiz | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 2.67 | |
NM_017373 | Nfil3 | nuclear factor, interleukin 3, regulated | 12.68 | 3.34 |
NM_144892 | Ncoa5 | nuclear receptor coactivator 5 | 14.65 | |
NM_173440 | Nrip1 | nuclear receptor interacting protein 1 | 2.87 | |
BC032981 | Nfxl1 | nuclear transcription factor, X-box binding-like 1 | 3.13 | |
NM_020005 | Pcaf | P300/CBP-associated factor | 2.33 | |
NM_027924 | Pdgfd | platelet-derived growth factor, D polypeptide | 6.17 | |
NM_017463 | Pbx2 | pre B-cell leukemia transcription factor 2 | 2.84 | |
NM_026383 | Pnrc2 | proline-rich nuclear receptor coactivator 2 | 2.08 | |
NM_145495 | Rin1 | Ras and Rab interactor 1 | 7.01 | 2.87 |
NM_011651 | Stk22s1 | serine/threonine kinase 22 substrate 1 | 2.36 | |
NM_175246 | Snip1 | Smad nuclear interacting protein 1 | 2.07 | |
NM_007707 | Socs3 | suppressor of cytokine signaling 3 | 2.45 | |
NM_080843 | Socs4 | suppressor of cytokine signaling 4 | 2 | |
NM_009365 | Tgfb1i1 | transforming growth factor beta 1 induced transcript 1 | 2.22 | |
NM_0010130 | Tgfbrap1 | transforming growth factor, beta receptor associated protein 1 | 2.7 | |
NM_013869 | Tnfrsf19 | tumor necrosis factor receptor superfamily, member 19 | 2.4 | |
NM_010755 | Maff | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) | 2.92 | |
NM_009524 | Wnt5a | wingless-related MMTV integration site 5A | 8.25 | |
Transport | ||||
NM_007511 | Atp7b | ATPase, Cu++ transporting, beta polypeptide | 2.34 | |
NM_011075 | Abcb1b | ATP-binding cassette, sub-family B (MDR/TAP), member 1B | 4.65 | |
NM_008576 | Abcc1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 2.37 | |
NM_172621 | Clic5 | Chloride intracellular channel 5, mRNA | 2.39 | |
NM_024406 | Fabp4 | Fatty acid binding protein 4, adipocyte | 3.7 | |
NM_146188 | Kctd15 | potassium channel tetramerisation domain containing 15 | 2.82 | |
Kctd7 | potassium channel tetramerisation domain containing 7 | 2.65 | ||
NM_148938 | Slc1a3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 4.03 | |
NM_019481 | Slc13a1 | solute carrier family 13 (sodium/sulphate symporters), member 1 | 2.09 | |
NM_0010041 | Slc13a5 | solute carrier family 13 (sodium-dependent citrate transporter), member 5 | 6.88 | |
NM_011395 | Slc22a3 | solute carrier family 22 (organic cation transporter), member 3 | 2.07 | |
NM_172980 | Slc28a2 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 | 2 | |
NM_078484 | Slc35a2 | solute carrier family 35 (UDP-galactose transporter), member 2 | 6.5 | |
NM_011990 | Slc7a11 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 | 5.93 | |
NM_080852 | Slc7a12 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 | 2.95 | |
NM_011406 | Slc8a1 | Solute carrier family 8 (sodium/calcium exchanger), member 1 | 2.86 | |
NM_178892 | Tiparp | TCDD-inducible poly(ADP-ribose) polymerase | 2.27 | |
Ubiquitination and Proteolysis | ||||
NM_027926 | Cpa4 | carboxypeptidase A4 | 2.29 | |
NM_011931 | Cop1 | Constitutive photomorphogenic protein | 2.52 | |
NM_013868 | Hspb7 | heat shock protein family, member 7 (cardiovascular) | 2.25 | |
NM_146042 | Ibrdc2 | IBR domain containing 2 | 6.77 | |
NM_009174 | Siah2 | seven in absentia 2 | 2.46 | |
Siah2 | seven in absentia 2 | 2.12 | ||
NM_025692 | Ube1dc1 | ubiquitin-activating enzyme E1-domain containing 1 | 2.79 | |
NM_173443 | Vcpip1 | valosin containing protein (p97)/p47 complex interacting protein 1 | 2.12 | |
Molecular chaperones and Heat Shock Proteins | ||||
NM_0010124 | Hspb6 | heat shock protein, alpha-crystallin-related, B6 | 2.13 | |
NM_010918 | Nktr | natural killer tumor recognition sequence | 2.02 | |
NM_030201 | Stch | stress 70 protein chaperone, microsome-associated, human homolog | 2.47 | |
Stch | stress 70 protein chaperone, microsome-associated, human homolog | 2.37 | ||
Miscellaneous | ||||
NM_008161 | Gpx3 | glutathione peroxidase 3 | 5.79 | |
NM_028733 | Pacsin3 | Protein kinase C and casein kinase II substrate 3 (Pacsin3) | 2.12 | |
NM_009409 | Top2b | Topoisomerase (DNA) II beta (Top2b), mRNA | 3.39 | |
NM_020283 | B3galt1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 2.45 |
Genes that were induced >2-fold by TM only in small intestine of Nrf2 wild-type mice but not in small intestine of Nrf2 knockout mice compared with vehicle treatment at 3h. The relative mRNA expression levels of each gene in treatment group over vehicle group (fold changes) are listed.
Genes that were induced >2-fold by TM only in liver of Nrf2 wild-type mice but not in liver of Nrf2 knockout mice compared with vehicle treatment at 3h. The relative mRNA expression levels of each gene in treatment group over vehicle group (fold changes) are listed.