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. Author manuscript; available in PMC: 2007 Nov 10.
Published in final edited form as: Biochem Biophys Res Commun. 2006 Sep 18;350(1):214–219. doi: 10.1016/j.bbrc.2006.09.032

Fig. 1.

Fig. 1

A diagram depicting the two zinc-dependent deaminase (ZDD) domains of human APOBEC3G (hA3G) and the regions homologous to the bipartite NLS and NES regions of hAPOBEC-1 and hAID. The sequence homologies of the bipartite NLS are shown in the boxed regions in hAPOBEC-1 and hAID. The underlined region in hA3G, demonstrates that a bipartite NLS is not conserved in hA3G. The NES homologies show three conserved leucines (boxed) and one leucine not conserved (underlined) in both the N-terminal (hA3G-NT) and C-terminal (hA3G-CT) regions of hA3G corresponding to critical leucines that make up the NES regions of hAPOBEC-1 and hAID, respectively (the human sequences are representative of the respective regions of APOBEC-1, AID and A3G in a multitude of mammalian species). The consensus NLS and NES are indicated below the respective homologies where x means any amino acid and B means basic amino acids lysine and arginine.

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