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. 2007 Apr 2;104(15):6247–6252. doi: 10.1073/pnas.0701509104

Fig. 5.

Fig. 5.

Conditional Axin expression in Pdx1+ progenitors impairs β cell development. (A–D) Immunofluorescent detection of insulin+ (green) and glucagon+ (red) cells in WT (A) and Pdx1-tTA/TRE-Axin (B) islets (no Dox) and in WT (C) and Pdx1-tTA/TRE-Axin (D) islets administered Dox from the time of conception. (Original magnification: ×100.) (E and F) The relative insulin+ (E) and glucagon (F) area per islet compared in WT and Pdx1-tTA/TRE-Axin mice and in WT and Pdx1-tTA/TRE-Axin mice administered Dox from the time of conception. (E) The P value for insulin+ area between Pdx1-tTA/TRE-Axin islets and control islets is ≤0.02. (F) The P value for glucagon+ area among all genotypes is not significant. (G) Morphometric analysis of insulin+ area as a percentage of total pancreas area from P28 WT and Pdx1-tTA/TRE-Axin mice. (H) Total insulin (nanograms) per pancreas (milligrams) in P28 Pdx1-tTA/TRE-Axin and WT mice. All data are from at least three litters, with four to eight mice per genotype. Data are presented as the average ± SEM.