Table 2.
LukF 40 nM | LukF 2 nM | LukF-T5C-T21C | LukF-S8C-K20C | |
4(a) | 15(a) | 9.6(a) | 9.6(a) | |
LukS 1 nM | 9.6(b) | 31(b) | 18.5(b) | 18.5(b) |
25(c) | 48(c) | 35(c) | 35(c) | |
6(a) | ||||
LukS 0.1 nM | 12.5 | n.d. | n.d. | n.d. |
35 | ||||
22(a) | 12(a) | 22(a) | ||
LukS-D1C-R16C | 45.5(b) | n.d. | 28(b) | 36(b) |
70(c) | 45.4(c) | 50.2(c) | ||
6(a) | 6.5(a) | 22(a) | ||
LukS-(-1C)-R16C | 12.5(b) | n.d. | 17(b) | 36(b) |
30(c) | 40(c) | 48.8(c) | ||
2(a) | 6.5(a) | 3(a) | ||
LukS-N2C-R16C | 8.6(b) | n.d. | 17(b) | 15(b) |
25(c) | 40(c) | 35(c) |