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. 2007 Feb 28;2007:25935. doi: 10.1155/2007/25935

Table 2.

Times (min) to reach (a) 5%, (b) 50%, and (c) 100% of the entry of ethidium into cells by pores formed by combinations of PVL (taken as reference) and its mutants.

LukF 40 nM LukF 2 nM LukF-T5C-T21C LukF-S8C-K20C

4(a) 15(a) 9.6(a) 9.6(a)
LukS 1 nM 9.6(b) 31(b) 18.5(b) 18.5(b)
25(c) 48(c) 35(c) 35(c)
6(a)
LukS 0.1 nM 12.5 n.d. n.d. n.d.
35
22(a) 12(a) 22(a)
LukS-D1C-R16C 45.5(b) n.d. 28(b) 36(b)
70(c) 45.4(c) 50.2(c)
6(a) 6.5(a) 22(a)
LukS-(-1C)-R16C 12.5(b) n.d. 17(b) 36(b)
30(c) 40(c) 48.8(c)
2(a) 6.5(a) 3(a)
LukS-N2C-R16C 8.6(b) n.d. 17(b) 15(b)
25(c) 40(c) 35(c)