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. Author manuscript; available in PMC: 2007 Apr 4.
Published in final edited form as: Mol Cell. 2007 Feb 9;25(3):455–462. doi: 10.1016/j.molcel.2007.01.013

Figure 2.

Figure 2

The Sec4p binding surface and conservation. (A) Surface representation of Sec2p. Residues within 4 Å of Sec4p are purple. (B) Residues identical in Sec2p and the mammalian Rabin3/8 and GRAB proteins are purple; similar residues (R=K, D=E, I=L=V) are magenta. (C) Sequence alignment of the Sec2p GEF domain with Rabin3/8 (human isoform β1) and GRAB (Rattus norvegicus). Identical and similar residues are purple and magenta, respectively. The Rabin3 and Rabin8 sequences are almost identical. Residues in Sec2p within 4 Å of Sec4p are boxed.