Fig. 1.
Illustrates the locomotor activity of rats during the pretreatment period. Rats received 20.0 mg/kg of cocaine or saline for 10 days from ages PND 35–44 or PND 70–79. Locomotor activity was recorded on day 1, day 5 and day 10. A) Shows that the total distance moved (cm) in cocaine treated rats was significantly higher on day 1 than on days 5 and 10. B) Average stereotypy scores from rats injected with cocaine significantly increased from day 1 to day 5 to day 10, showing that repeated cocaine enhanced the behavioral response. * indicates significant difference from cocaine pretreated rats on day 1.