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. Author manuscript; available in PMC: 2007 Jun 1.
Published in final edited form as: J Neurochem. 2006 Sep;98(5):1474–1486. doi: 10.1111/j.1471-4159.2006.04000.x

Figure 4. Involvement of 12-lipoxygenase in homocysteic acid induced neuronal death and its sensitivity to α-tocotrienol.

Figure 4

A, Western blot demonstrating over-expression of 12-lipoxygenase (12-Lox) in HT4 cells. pcDNA3.1, empty plasmid control; pcDNA3.1+12-Lox, 12-Lox expression vector. B, 12-Lox over-expression accelerated HCA-induced cell death. Both TCT (0.25μM) as well as BL15 (2.5μM) protected against the toxic effects of 12-Lox. *, lower than group treated with HCA alone; †, HCA induced more toxicity in 12-Lox over-expressing cells than in control cells. TCT, α-tocotrienol.