Table 4.
MHC | Peptide | Anti-CD8 mAba | Concentration of peptide that elicits 50% of the maximum response (M) |
---|---|---|---|
Kbm8 | pBM8 | − | 2 × 10−8 |
Kbm8 | pBM8 | + | Total inhibition |
Kbm8 | pBM8Y4D | − | 10−15 |
Kbm8 | pBM8Y4D | + | Partial inhibition |
Kbm8 | pBM8Y4V | − | 3 × 10−10 |
Kbm8 | pBM8Y4V | + | Total inhibition |
Kb | pBM1 | − | <10−15 |
Kb | pBM1 | + | No inhibition |
Kb | pBM1D4Y | − | 10−11 |
Kb | pBM1D4Y | + | Total inhibition |
Kb | pBM1D4V | − | <10−15 |
Kb | pBM1D4V | + | Partial inhibition |
An anti-CD8 monoclonal antibody was added during the cytotoxic assay at a concentration of 10 μg/ml. |