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. 2007 Mar 15;26(7):1972–1983. doi: 10.1038/sj.emboj.7601605

Table 4.

Peptide concentration required for half-maximum cytolysis by BM3.3 T-cell effectors in the presence or absence of an anti-CD8 antibody

MHC Peptide Anti-CD8 mAba Concentration of peptide that elicits 50% of the maximum response (M)
Kbm8 pBM8 2 × 10−8
Kbm8 pBM8 + Total inhibition
Kbm8 pBM8Y4D 10−15
Kbm8 pBM8Y4D + Partial inhibition
Kbm8 pBM8Y4V 3 × 10−10
Kbm8 pBM8Y4V + Total inhibition
Kb pBM1 <10−15
Kb pBM1 + No inhibition
Kb pBM1D4Y 10−11
Kb pBM1D4Y + Total inhibition
Kb pBM1D4V <10−15
Kb pBM1D4V + Partial inhibition
An anti-CD8 monoclonal antibody was added during the cytotoxic assay at a concentration of 10 μg/ml.