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. 2007 Mar 8;26(7):1924–1933. doi: 10.1038/sj.emboj.7601639

Figure 2.

Figure 2

Excitatory inputs to PCs in JP-DKO cerebellum. (A) Frequency histograms of PCs in terms of the number of discrete CF-EPSC steps. Wild type (WT) n=39, JP-DKO n=38. (B) Paired-pulse depression of CF-EPSCs recorded from PC in WT (n=9) and JP-DKO (n=12) mice. Mean±s.e.m. The amplitude of the second response is expressed as a percentage of the first response and is plotted along the interpulse intervals. (C) Paired-pulse facilitation of PF-mediated EPSCs recorded from WT (n=11) and JP-DKO (n=12) mice. Mean±s.e.m. The PF-EPSCs were examined as in (B), and the data suggest that irregular transmission could occur at high-frequency PF stimuli. *P<0.05, **P<0.01, significantly different from the value for WT mice (t-test). Data are obtained from 5- to 9-week-old mice.