Table 1.

Nineteen deaths causally associated with Lariam (mefloquine) use

Reference	Patient nationality	Patient age	Clinical details
18	American (USA)	Not stated	After one mefloquine tablet, patient experienced cardiopulmonary arrest, death.
19	Thai	13	Malaria recrudesced 21 days after mefloquine treatment. Given halofantrine over 3 days. Experienced sudden cardiac arrest, death.
20	British	6	Developed blistering of lips and oral mucosae. Generalized erythema and blistering, then exfoliation of the mucosae. Ulceration of the mucosae, hair and nail loss. Cardiac asystole, death.
21	British	37	After taking Lariam for overseas trip, became acutely depressed. Committed suicide by jumping to his death from the roof of a mansion block.
22	German	33	Took two Lariam tablets for suspected malaria. After 4 hours, experienced headaches, `burning in bones', deafness, dizziness. Confused, panic, depression. Hospitalized. Committed suicide.
23	American (USA)	22	Early during mefloquine prophylaxis, experienced fever (102 degrees), chills, headache, cough. Initially treated as malaria. Then, during a 2-hour car ride, experienced a `head rush.' Collapsed, died.
24	British	Not stated	Eight fatal reactions to mefloquine, reported to the UK Medicines Control Agency.
25	Not stated	Not stated	Four fatal reactions to Lariam, recorded on the manufacturer's database of adverse drug reactions.
26	French	27	Treated with Lariam for 48 hours. Committed suicide 6 weeks later, through selfinflicted multiple knife wounds.