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. Author manuscript; available in PMC: 2007 Apr 5.
Published in final edited form as: Neuropsychopharmacology. 2006 Jan;31(1):77–89. doi: 10.1038/sj.npp.1300791

Figure 4.

Figure 4

Effect of risperidone pretreatment on amphetamine-stimulated locomotion. (a) Locomotor responses (crossovers per 15 min interval) following amphetamine (1.5 mg/kg) injection on PD 57 of lesioned and sham-lesioned rats treated on PD 35–56 with saline or risperidone (45 or 85 μg/kg). Data are expressed as mean crossovers; error bars are 95% confidence intervals. (b) Risperidone treatment effects (45 or 85 μg/kg) determined from [μ{Lesion/Risp x μg/kg}−μ{Sham/Risp x μg/kg}]−[μ{Lesion/Saline}−μ{Sham/Saline}]. Negative values indicate suppression of the hyperlocomotor effect of hippocampal lesions (0). Note that the protective effect of 45 μg/kg risperidone emerges over time, becoming statistically significant after 30 min. Data are expressed as mean ±95% confidence intervals. *P ≤0.05, **P≤0.01 vs lesion group.