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. Author manuscript; available in PMC: 2007 Apr 5.
Published in final edited form as: Neuropsychopharmacology. 2006 Jan;31(1):77–89. doi: 10.1038/sj.npp.1300791

Figure 5.

Figure 5

Effect of risperidone pretreatment on locomotion following change between light and dark cycle. (a) Locomotor response (crossovers per 15 min interval) during the first 120 min of the ‘lights-out’ period in the RACs on PD 57 of lesioned and sham-lesioned animals following pretreatment with saline or risperidone (45 or 85 μg/kg) on PD 35–56. Data are expressed as mean crossovers; error bars are 95% confidence intervals. (b) Risperi-done treatment effects (45 or 85 μg/kg) determined from [μ{Lesion/Risp x μg/kg}−μ{Sham/Risp x μg/kg}]−[μ{Lesion/Saline}−μ{Sham/Saline}]. Negative values indicate suppression of the hyperlocomotor effect of hippocampal lesions (0). Data are expressed as mean ±95% confidence intervals. *P≤0.05, **P≤0.01, ***P≤0.001 vs lesion group.