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. Author manuscript; available in PMC: 2008 Feb 15.
Published in final edited form as: Neuron. 2007 Feb 15;53(4):495–502. doi: 10.1016/j.neuron.2007.01.027

Figure 1.

Figure 1

NR2A-deficient mice express normal levels of synaptic NR1, NR2B, and GluR1 subunits. The Western blot illustrates representative examples of NR2A, NR1, GluR1, NR2B, and synapsin (Syn) immunoreactive bands from the synaptoneurosome preparation in +/+, +/−, and −/− mice aged P21-P29. For quantification, receptor subunit levels were divided by synapsin levels to control for loading and efficiency of synaptic enrichment in the synaptoneurosome preparation, and the resulting ratio was normalized to the average value for +/+ mice (see Table 1). Note that NR2A levels were reduced to roughly half of control levels in +/− mice and absent in −/− animals, while NR1, NR2B, and GluR1 levels were not affected by the genetic manipulation.