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. 2007 Mar 24;6:1. doi: 10.1186/1475-9268-6-1

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Copyright © 2007 Fabian et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schematic diagram showing the relationships between myosin and its activators and inhibitors. In order for myosin to be active, its regulatory light chain (MRLC) has to be phosphorylated either by myosin light chain kinase (MLCK) or by Rho-associated kinase (Rho-K). Dephosphorylation of MRLC is done by myosin light chain phosphatase (MLCPase). Various inhibitors interfere with myosin activity: Rho-K is inhibited by Y-27632, MLCPase is inhibited by Calyculin A and myosin is inhibited by BDM.