Figure 7.

Survival of PLSJL mice immunized with MBP in CFA and treated with 10 mg of uric acid once, twice, or four times daily starting at 5 or 24 days after immunization. Shown are the survival curves of the mice described in the legend to Fig. 6. Starting 5 days after immunization with MBP and continuing for 30 days, the groups of 10 mice were treated with 10 mg of uric acid i.p. once (○), twice (◊), or four (□) times daily or with saline (▴). A group of seven mice surviving without treatment to 24 days after immunization received four doses per day starting at that point (▪) through day 35 after immunization.