Figure 4.

Absence of cornified cell envelopes in scales from a patient with TGase-negative lamellar ichthyosis. (A) Cornified cell envelopes in corneocytes scraped from normal human. (B) Absence of envelopes in corneocytes from a patient with lamellar ichthyosis. (C) Presence of dense envelopes in corneocytes of a patient with Netherton syndrome. Assays for TGase in the insoluble fraction of these corneocytes gave values 10.6 times higher than those of B, whose small amount of enzyme activity we attribute to TGase2.