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. 1998 Jan 20;95(2):725–729. doi: 10.1073/pnas.95.2.725

Figure 2.

Figure 2

Hematologic reconstitution and long-term graft function after transplantation of purified or unseparated mobilized peripheral blood (PB) or steady-state bone marrow (BM) grafts. (A and B) Groups of 10 mice were transplanted with purified PB-derived WGA+/Lin−/Rho− cells only (200 or 600 cells per mouse) or in combination with an excess number of Rho+/++ cells (10,000 cells per mouse). (C–F) Groups of 20 mice were transplanted with unseparated BM-derived (2 × 104, 2 × 105, or 2 × 106 cells; dashed lines) or PB-derived (5 × 104, 5 × 105, or 5 × 106 cells; solid lines) grafts. The respective BM and PB grafts contained equal numbers of Rho− cells (±70, ±700, and ±7,000, respectively), and the PB grafts contained 7-fold more Rho+/++ cells and 5-fold more committed progenitor cells (see Table 1). By using a two-tailed t test for paired samples, a significant (P < 0.05) difference was observed for the means of platelet and white blood cell counts on days 15, 18, 22, 26, and 30 between the groups transplanted with 200 or 600 Rho− cells. No difference was observed for platelet (P = 0.25) and white blood cell counts (P = 0.45) between the groups transplanted with 200 Rho− cells only or 200 Rho− cells in combination with 10,000 Rho+/++ cells.