Table 4.

Mixed-effects models^a for the impact of prenatal exposure to p,p′-DDE on infant psychomotor and mental development throughout the first year of life.

	PDI			MDI
Variable	Coefficient	95% CI	p-Value	Coefficient	95%CI	p-Value
p,p′-DDE (ng/mL)b
1st trimester	− 0.52c	−0.96 to −0.075	0.02	−0.06c	−0.36 to 0.24	0.69
2nd trimester	0.23c	−0.22 to 0.69	0.32	−0.12c	−0.43 to 0.20	0.47
3rd trimester	0.16c	−0.30 to 0.62	0.50	0.07c	−0.24 to 0.40	0.64
Age at evaluation (months)d
3	−10.80	−12.10 to −9.45	0.000	−2.59	−3.55 to −1.63	0.000
6	−1.94	−3.46 to −0.42	0.01	−1.24	−2.24 to −0.24	0.01
12	−5.72	−7.46 to −3.98	0.000	−3.30	−4.67 to −1.91	0.000
Breast-feeding (yes)	1.14	−0.34 to 2.62	0.13	1.14	0.08 to 2.20	0.03
HOME Scale	0.24	0.10 to 0.40	0.001	0.14	0.04 to 0.24	0.005
Birth weight (kg)	2.60	1.04 to 4.20	0.001	2.14	1.07 to 3.21	0.000

^aGeneralized mixed models effects, with the subject as a random intercept and random slopes of age at evaluation and age-squared for PDI models. MDI models only included subject as a random intercept and random slope of age at evaluation. Models were adjusted for birth weight, age at evaluation, breast-feeding, and HOME Scale at 6 months of age.

^blog₂DDE.

^cFor each doubling of p,p′-DDE.

^dCompared with evaluation at 1 month of age.