Table 2.

Putative Functions of p27^Kip1

“Universal” cyclin-dependent kinase inhibitor that regulates progression through the cell cycle. 1-7,14,16,18
Potential tumor suppressor gene. 44-47
Promoter of apoptosis. 37,38
Regulator of drug resistance in solid tumors. 35
Role in cell differentiation in muscle, oligodendrocytes, osteoblasts, and granulosa cells. 39-42
Safeguard against inflammatory injury. 43