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. 1999 Feb;154(2):553–566. doi: 10.1016/s0002-9440(10)65301-1

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Copyright © 1999, American Society for Investigative Pathology

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Figure 6. — Ultrastructural features of osteoclasts in a young (A) or an aged (B) op/op mouse and a GM-CSF-treated (C) or an IL-3-treated (D) young op/op mouse. A: Osteoclast in the young op/op mouse has a slender nucleus, contains cytoplasmic vesicles, vacuoles, and granules, and develops poor ruffled borders (arrow). B: Mononuclear osteoclast in the aged op/op mouse possesses an elongated nucleus, and its cytoplasm is more copious, contains much more numerous vesicles, vacuoles, and granules, and develops ruffled borders more markedly than in the young op/op mouse. An arrow indicates the development of ruffled borders. C: Mononuclear osteoclast has a large round nucleus with a copious cytoplasm, developing ruffled borders (arrow) and containing numerous vesicles, vacuoles, and granules in the GM-CSF-treated young op/op mouse. D: Mononuclear osteoclast in the IL-3-treated young op/op mouse is similar to that in the GM-CSF-treated one and developing ruffled borders (arrow). Magnification, ×4000 (A and B) and ×3500 (C and D).