Table 2.
Immunohistochemical Analysis of CEACAM6 and CEACAM7 Expression in Different Normal Organs and Tissues
| Monoclonal antibody antigen recognized | 9A6 | BAC2 | Expression pattern |
|---|---|---|---|
| CEACAM6 | CEACAM7 | ||
| Tongue | + | − | Upper third of squamous epithelia |
| Esophagus | + | − | Squamous epithelia |
| Stomach body | + | − | Single crypts, luminal cells |
| Duodenum | − | − | |
| Jejunum | − | − | |
| Ileum | − | − | |
| Appendix | + | + | Epithelia, upper fifth of crypt for each antigen |
| Colon | + | + | Epithelia, upper fifth of crypt for each antigen |
| Thyroid gland | − | − | |
| Submandibular salivary gland | + | − | Mucous epithelia most prominent |
| Anterior lingual gland | + | − | Mucous epithelia most prominent |
| Pancreas | + | + | Small ducts, with BAC2 only individual cells |
| Breast | + | − | Some breast ducts |
| Adrenal gland | − | − | |
| Liver | + | − | Granulocytes |
| Gall bladder | + | − | Apical epithelia |
| Lung | + | − | Pneumocytes, bronchiole epithelia, granulocytes |
| Kidney | − | − | |
| Bladder | − | − | |
| Skin | + | − | Eccrine sweat glands, hair follicles, squamous epithelia |
| Bone marrow | + | − | Myeloid cells |
| Tonsils | + | − | Epithelia and granulocytes |
| Spleen | + | − | Myeloid cells |
| Prostate gland | + | − | Single ducts |
| Fallopian tube | − | − | |
| Cervix | + | − | Squamous epithelia |
| Uterus | − | − | |
| Ovary | − | − | |
| Testis | − | − | |
| Seminal vesicle | − | − | |
| Epididymus | − | − | |
| Heart | − | − | |
| Urether | − | − | |
| Umbilical cord | + | − | Amnion epithelia |
| Placenta | + | − | Amnion epithelia |