Table 3.
Expression of CEACAM6 and CEACAM7 in Polyps and Adjacent Mucosa
| Polyp | Polyp size (mm) | CEACAM7 expression* | CEACAM6 expression† | ||
|---|---|---|---|---|---|
| Polyp | Normal mucosa | Polyp | Normal mucosa | ||
| Hyperplastic polyps | |||||
| 1‡ | 0.5 × 1.0 | − | − | ++ | + |
| 2 | 1.5 × 0.5 | − | + | +/− | + |
| 3‡ | 1.0 × 1.0 | − | − | ++ | + |
| 4‡ | 1.5 × 1.0 | − | − | ++ | + |
| 5 | 2.0 × 0.5 | − | + | ++ | + |
| 6 | 2.0 × 2.0 | − | + | + | + |
| 7‡ | 2.0 × 2.0 | − | − | ++ | + |
| 8‡ | 2.0 × 2.0 | − | − | ++ | + |
| Tubular adenomas | |||||
| 9‡ | 1.5 × 1.0 | − | − | ++ | + |
| 10‡ | 2.0 × 1.5 | − | − | ++ | + |
| 11 | 2.0 × 1.5 | − | + | + | + |
| 12 | 2.5 × 2.0 | − | + | ++ | + |
| 13 | 3.0 × 2.0 | − | + | ++ | + |
| 14‡ | 3.0 × 3.0 | − | − | ++ | + |
| 15 | 4.0 × 2.0 | − | + | + | + |
| 16‡ | 5.0 × 5.0 | − | − | ++ | + |
| 17 | >5 | − | + | ++ | + |
| 18 | <5 | − | + | ++ | + |
| 19 | <10 | − | + | ++ | + |
| 20 | 14.0 × 12.0 | − | − | ++ | + |
| Tubulovillous adenomas | |||||
| 21 | 4.0 × 4.0 | − | + | ++ | + |
| 22 | <5 | − | + | ++ | + |
| 23 | >5 | − | + | ++ | + |
| 24 | 11.0 × 11.0 | − | + | ++ | + |
| Adenoma with atypia | |||||
| 25 | 14.0 × 10.0 | − | + | ++ | + |
*Expression of CEACAM7 was found on the apical surface of epithelial cells from the upper fifth of the crypts (+) or was absent (−); it was always absent from polyps.
†Expression of CEACAM6 in polyps revealed either a broader expression zone (++), or was comparable (+), or was reduced (+/−) compared to the adjacent mucosa (+).
‡These tissue samples were fixed with formaldehyde for more than 4 days; all other samples were unfixed or fixed for <2 days.