Table 1.

Relationship between the Expression of u-PA, u-PAR, and PAI-2 Protein and Various Clinicopathological Factors

Characteristics	u-PA						u-PAR			PAI-2
	Cancer cells			Fibroblasts			Cancer cells			Cancer cells			Fibroblasts
	Posi- tive	Nega- tive	P value	Posi- tive	Nega- tive	P value	Posi- tive	Nega- tive	P value	Posi- tive	Nega- tive	P value	Posi- tive	Nega- tive	P value
No. of patients	13	43		12	44		14	42		10	46		25	31
Age
Mean	58.8	63.3	N.S.‡	62.4	62.2	N.S.	63.2	59.1	N.S.	62.3	62.2	N.S.	59.5	64.4	N.S.
Range	46–73	27–78		50–72	27–78		44–78	27–72		50–69	27–78		27–74	46–78
Sex
Male	13	41	N.S.	11	43	N.S.	41	13	N.S.	9	45	N.S.	24	30	N.S.
Female	0	2		1	1		1	1		1	1		1	1
Histological type*
Well	6	14	N.S.	5	15	N.S.	4	16	N.S.	4	16	N.S.	11	9	N.S.
Moderately	5	21		4	22		8	18		4	22		12	14
Poorly	2	7		3	6		1	8		1	8		2	7
Basal cell carcinoma	0	1		0	1		1	0		1	0		0	1
T category†
pT1, pT2	2	22	P < 0.05	4	20	N.S.	6	18	N.S.	5	19	N.S.	15	9	P < 0.05
pT3, pT4	11	21		8	24		8	24		5	27		10	22
N category†
pN0	1	20	P < 0.05	4	17	N.S.	4	17	N.S.	4	17	N.S.	12	9	N.S.
pN1	12	23		8	27		10	25		6	29		13	22
Lymphatic invasion†
Negative	1	10	N.S.	2	9	N.S.	1	10	N.S.	0	11	N.S.	6	5	N.S.
Positive	12	33		10	35		13	32		10	35		19	26
Vascular invasion†
Negative	6	23	N.S.	4	25	N.S.	8	21	N.S.	3	26	N.S.	12	17	N.S.
Positive	7	20		8	19		6	21		7	20		13	14
Prospective hepatic‡ metastases
Negative	9	41	P < 0.05	11	39	N.S.	12	38	N.S.	9	41	N.S.	24	26	N.S.
Positive	4	2		1	5		2	4		1	5		1	5
Prospective distant‡ metastases
Negative	0	41	P < 0.001	10	31	N.S.	11	30	N.S.	9	32	N.S.	19	22	N.S.
Positive	13	2		2	13		3	12		1	14		6	9

*Well, well-differentiated squamous carcinoma; moderately, moderately differentiated squamous carcinoma; poorly, poorly differentiated squamous carcinoma.

^†At operation.

^‡During the period of follow up.

N.S., not significant (Fisher’s exact probability test).