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. 2000 Feb;156(2):425–432. doi: 10.1016/S0002-9440(10)64746-3

Figure 3.

Figure 3.

Differential PCR assay for p16 homozygous deletion and CDK4 and MDM2 amplification. Both gliomatous (G) and sarcomatous (S) areas in case 220 show a significantly increased signal intensity of the CDK4 and MDM2 bands (*) when compared to the respective reference sequence (IFNG, DR), suggesting coamplification of these genes. In case 214 (bottom), both tumor components show a reduced p16 signal (*) when compared to the reference sequence (9q STS), suggesting a homozygous p16 deletion. N, normal DNA; M, molecular size marker.