Table 1.
Reactivity of the Autoimmune and Control Sera with the Two Forms of Collagen XVII and the Recombinant Domains*
| Disorder | No. of sera tested | Immunopositive sera | ||||
|---|---|---|---|---|---|---|
| Full-length collagen XVII | Shed ectodomain | Recombinant domains | ||||
| NC16a | Col15 | Ecto2 | ||||
| Bullous pemphigoid | 43 | 34 | 29 | 21 | 11 | 17 |
| Cicatricial pemphigoid | 6 | 6 | 6 | 1 | 3 | 3 |
| Gestational pemphigoid | 1 | 0 | 0 | 0 | 0 | 0 |
| LAD | 24 | 9 | 12 | 2 | 2 | 1 |
| CBDC | 7 | 3 | 7 | 0 | 1 | 0 |
| Pemphigus group | 44 | 2 | 1 | 0 | 0 | 0 |
| Others† | 30 | 0 | 0 | 0 | 0 | 0 |
* LAD indicates linear IgA dermatosis and CBDC chronic bullous disease of childhood. The pemphigus group contains pemphigus vulgaris, pemphigus foliaceus, and pemphigus erythematosus.
† Others include control sera from eczema, psoriasis, and nonbullous autoimmune skin diseases.