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. 2000 Jun;156(6):2123–2133. doi: 10.1016/S0002-9440(10)65083-3

Figure 2.

Figure 2.

Representative gels and proposed genetic pathways for case G2. Gel for D9S1749 shows homogeneous LOH at 9p for all dysplastic and invasive foci (T1–T5, T7–T11, T15). Hyperplastic foci (T6 and T12) retained all alleles tested. Subsequent and divergent LOH at 18q is shown with two different markers (D18S487 and D18S55) to clarify the true nature of the heterogeneous patterns and to exclude spurious PCR reactions. Arrowheads indicate loss of the lower allele (18q-β: T8, T10, T15). Other foci except hyperplastic foci showed loss of the upper allele (18q-α). Further divergence of LOH at 3p (D3S1293 and D3S1286) in invasive foci (T4, T5, and T11) is shown by arrows. *, Normal alleles; N, normal control DNA; T#, microdissected foci.