Table 5.
Statistical Analysis (Kaplan-Meier Analysis) of Clinicopathological Parameter and Labeling Indexes of Immunohistochemical Staining in Leiomyosarcoma
| Parameter | Log rank test, P value |
|---|---|
| Size (</=, >5 cm) | |
| Recur* | N.S.¶ |
| Meta† | P < 0.02 |
| Survival‡ | P < 0.05 |
| Location (cutis/deeper) | |
| Recur | N.S.¶ |
| Meta | N.I.∥ |
| Survival | N.I.∥ |
| Mitosis (</=, >6)§ | |
| Recur | P < 0.05 |
| Meta | N.S.¶ |
| Survival | N.S.¶ |
| Cyclin A (</=, >10%) | |
| Recur | P < 0.01 |
| Meta | P < 0.05 |
| Survival | P < 0.05 |
| Cyclin E (0 or >0%) | |
| Recur | N.S.¶ |
| Meta | P < 0.02 |
| Survival | P < 0.05 |
*Recur, local recurrence (all cases analyzed).
†Meta, metastasis-free survival period (only cases of deeper LMS analyzed).
‡Survival; overall survival period (only cases of deeper LMS analyzed).
§Six mitoses/10 high-power-field.
¶N.S.; not significant.
∥N.I.; not included for analysis.
Note: Since cutaneous leiomyosarcoma never metastasizes, we analyzed recurrence in all cases of LMS, and metastasis and overall survival in deep LMS cases. Accordingly, for the analysis of metastasis and overall survival, parameter location was not included.