Table 2.
Viral Loads and Extracellular Proportions of Tissue p24 or HIV-1 RNA
| Week | Biopsies (N) | Viral load (log10 HIV-1 RNA copies) | Extracellular HIV-1 (fluorescent microscopy) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| per ml plasma | per mg tonsil tissue | IHC (p24) | ISH (HIV-1 RNA) | ||||||
| Pos. (N)* | VL (90% CI)† | Pos. (N)* | VL (90% CI)† | Pos. (N)* | %Xcell (90% CI)† | Pos. (N)* | %Xcell (90% CI)† | ||
| 0 | 13 | 13 | 4.11 (0.33) | 13 | 5.08 (0.25) | 13 | 98 (0.7) | 13 | 88 (8.1) |
| 4 | 13 | 11 | 2.10 (0.54) | 13 | 3.74 (0.30) | 13 | 84 (16) | 9 | 99 (0.2) |
| 24 | 13 | 8 | 1.64 (0.71) | 12 | 2.75 (0.67) | 9 | 90 (15) | 5 | 100 (na)‡ |
| 48 | 11 | 5 | 1.09 (0.70) | 10 | 2.05 (0.66) | 6 | 82 (27) | 2 | 73 (44) |
*Pos. (N), number of samples with detectable HIV-1 RNA or p24.
†90% CI, ± 90% confidence interval; VL, viral load; %Xcell, average percent of detected p24 or HIV-1 RNA that was extracellular (positive specimens only).
‡na, not applicable because SD = 0.